Likelihood-Based Approach to Gene Set Enrichment Analysis with a Finite Mixture Model.
Stat Biosci
; 6(1): 38-54, 2014 May 01.
Article
em En
| MEDLINE
| ID: mdl-24891922
ABSTRACT
In this paper, we study a parametric modeling approach to gene set enrichment analysis. Existing methods have largely relied on nonparametric approaches employing, e.g., categorization, permutation or resampling-based significance analysis methods. These methods have proven useful yet might not be powerful. By formulating the enrichment analysis into a model comparison problem, we adopt the likelihood ratio-based testing approach to assess significance of enrichment. Through simulation studies and application to gene expression data, we will illustrate the competitive performance of the proposed method.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Stat Biosci
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos