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Severe acute hepatitis E in an HIV infected patient: Successful treatment with ribavirin.
Robbins, A; Lambert, D; Ehrhard, F; Brodard, V; Hentzien, M; Lebrun, D; Nguyen, Y; Tabary, T; Peron, J M; Izopet, J; Bani-Sadr, F.
Afiliação
  • Robbins A; Service de Médecine Interne et des Maladies Infectieuses et Tropicales, CHU Robert Debré, Reims, France.
  • Lambert D; Service de Médecine Interne et des Maladies Infectieuses et Tropicales, CHU Robert Debré, Reims, France.
  • Ehrhard F; Service de d'hepato-gastroenterologie, CHU Robert Debré, Reims, France.
  • Brodard V; Laboratoire de Virologie Médicale et Moléculaire, CHU Robert Debré, Reims, France.
  • Hentzien M; Service de Médecine Interne et des Maladies Infectieuses et Tropicales, CHU Robert Debré, Reims, France.
  • Lebrun D; Service de Médecine Interne et des Maladies Infectieuses et Tropicales, CHU Robert Debré, Reims, France.
  • Nguyen Y; Service de Médecine Interne et des Maladies Infectieuses et Tropicales, CHU Robert Debré, Reims, France.
  • Tabary T; Laboratoire d'Immunologie, CHU Robert Debré, Reims, France.
  • Peron JM; Service d'hepato-gastroenterologie, federation digestive, Hôpital Purpan, CHU de Toulouse, Toulouse, France.
  • Izopet J; Laboratoire de virologie, Hôpital Purpan, CHU de Toulouse, Toulouse, France.
  • Bani-Sadr F; Service de Médecine Interne et des Maladies Infectieuses et Tropicales, CHU Robert Debré, Reims, France. Electronic address: fbanisadr@chu-reims.fr.
J Clin Virol ; 60(4): 422-3, 2014 Aug.
Article em En | MEDLINE | ID: mdl-24894604
In industrialized countries, most cases of hepatitis E virus (HEV) infection in humans are autochthonous, mainly through foodborne and zoonotic transmission routes. In Europe, genotype 3 is a cause of acute self-limiting viral hepatitis, but can also be responsible for chronic hepatitis in immunocompromised patients. Ribavirin has been successfully used in the treatment of chronic hepatitis E and in a few cases of severe acute hepatitis E in immunocompetent patients. We report here the case of a 39 year-old man infected with HIV presenting with acute hepatitis E (genotype 3c). Unlike most cases, evolution was severe with a fall of prothrombin time down to 45%. Treatment with ribavirin allowed rapid viral clearance and a gradual normalization of liver function tests.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribavirina / Infecções por HIV / Hepatite E Limite: Adult / Humans / Male Idioma: En Revista: J Clin Virol Assunto da revista: VIROLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: França País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribavirina / Infecções por HIV / Hepatite E Limite: Adult / Humans / Male Idioma: En Revista: J Clin Virol Assunto da revista: VIROLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: França País de publicação: Holanda