Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.
ACS Med Chem Lett
; 1(7): 350-4, 2010 Oct 14.
Article
em En
| MEDLINE
| ID: mdl-24900218
ABSTRACT
Amalgamation of the structure-activity relationship of two series of GlyT1 inhibitors developed at Merck led to the discovery of a clinical candidate, compound 16 (DCCCyB), which demonstrated excellent in vivo occupancy of GlyT1 transporters in rhesus monkey as determined by displacement of a PET tracer ligand.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
ACS Med Chem Lett
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido