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PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling.
Moody, S E; Schinzel, A C; Singh, S; Izzo, F; Strickland, M R; Luo, L; Thomas, S R; Boehm, J S; Kim, S Y; Wang, Z C; Hahn, W C.
Afiliação
  • Moody SE; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA [2] Department of Medicine, Bringham and Women's Hospital and Harvard Medical School, Boston, MA, USA [3] Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Schinzel AC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Singh S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Izzo F; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Strickland MR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Luo L; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA [2] Department of Medicine, Bringham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Thomas SR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Boehm JS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kim SY; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
  • Wang ZC; 1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA [2] Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Hahn WC; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA [2] Department of Medicine, Bringham and Women's Hospital and Harvard Medical School, Boston, MA, USA [3] Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Oncogene ; 34(16): 2061-71, 2015 Apr 16.
Article em En | MEDLINE | ID: mdl-24909179
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinas / Neoplasias da Mama / Receptor ErbB-2 / Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases / Subunidades Catalíticas da Proteína Quinase Dependente de AMP Cíclico / Anticorpos Monoclonais Humanizados / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinas / Neoplasias da Mama / Receptor ErbB-2 / Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases / Subunidades Catalíticas da Proteína Quinase Dependente de AMP Cíclico / Anticorpos Monoclonais Humanizados / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido