Twisting and ironing: doxorubicin cardiotoxicity by mitochondrial DNA damage.

Nitiss, Karin C; Nitiss, John L

Nitiss, Karin C; Nitiss, John L.

Afiliação

Nitiss KC; Biomedical Sciences Department, UIC College of Medicine and Department of Biopharmaceutical Sciences, UIC College of Pharmacy, Rockford, Illinois.
Nitiss JL; Biomedical Sciences Department, UIC College of Medicine and Department of Biopharmaceutical Sciences, UIC College of Pharmacy, Rockford, Illinois. jlnitiss@uic.edu.

Clin Cancer Res ; 20(18): 4737-9, 2014 Sep 15.

Article em En | MEDLINE | ID: mdl-24916696

ABSTRACT

ABSTRACT

Anthracyclines are active clinical agents that have multiple mechanisms of cytotoxicity. Cardiotoxicity by anthracyclines limits the therapeutic potential of these agents, but mechanisms leading to cardiotoxicity remain controversial. Transgenic mice that lack mitochondrial topoisomerase I are hypersensitive to doxorubicin cardiotoxicity, providing support for cardiotoxicity arising from damage of mitochondrial DNA.

Assuntos

Antibióticos Antineoplásicos/toxicidade; Cardiotoxicidade/fisiopatologia; Dano ao DNA; DNA Mitocondrial/efeitos dos fármacos; Doxorrubicina/toxicidade; Coração/efeitos dos fármacos; Animais; Camundongos; Camundongos Transgênicos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / DNA Mitocondrial / Doxorrubicina / Cardiotoxicidade / Coração / Antibióticos Antineoplásicos Limite: Animals Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2014 Tipo de documento: Article

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