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Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor.
Trivella, Daniela B B; Pereira, Alban R; Stein, Martin L; Kasai, Yusuke; Byrum, Tara; Valeriote, Frederick A; Tantillo, Dean J; Groll, Michael; Gerwick, William H; Moore, Bradley S.
Afiliação
  • Trivella DB; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0212, USA; Institute of Chemistry, University of Campinas, Campinas SP 13083-970, Brazil; Brazilian Biosciences National Laboratory, National Center for Res
  • Pereira AR; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0212, USA.
  • Stein ML; Center for Integrated Protein Science, Department Chemie, Lehrstuhl für Biochemie, Technische Universität München, Garching 85747, Germany.
  • Kasai Y; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0212, USA.
  • Byrum T; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0212, USA.
  • Valeriote FA; Henry Ford Health System, Department of Internal Medicine, Josephine Ford Cancer Center, 440 Burroughs, Detroit, MI 48202, USA.
  • Tantillo DJ; Department of Chemistry, University of California at Davis, 1 Shields Avenue, Davis, CA 95616, USA.
  • Groll M; Center for Integrated Protein Science, Department Chemie, Lehrstuhl für Biochemie, Technische Universität München, Garching 85747, Germany. Electronic address: michael.groll@tum.de.
  • Gerwick WH; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0212, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093-0736, USA. Electronic address: w
  • Moore BS; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0212, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093-0736, USA. Electronic address: b
Chem Biol ; 21(6): 782-91, 2014 Jun 19.
Article em En | MEDLINE | ID: mdl-24930969
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Produtos Biológicos / Complexo de Endopeptidases do Proteassoma / Dipeptídeos / Alcenos / Inibidores de Proteassoma / Cetonas / Antineoplásicos Limite: Humans Idioma: En Revista: Chem Biol Assunto da revista: BIOLOGIA / BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Produtos Biológicos / Complexo de Endopeptidases do Proteassoma / Dipeptídeos / Alcenos / Inibidores de Proteassoma / Cetonas / Antineoplásicos Limite: Humans Idioma: En Revista: Chem Biol Assunto da revista: BIOLOGIA / BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos