Urokinase-type plasminogen activator biosynthesis is induced by the EJ-Ha-ras oncogene in CL26 mouse colon carcinoma cells.
Int J Cancer
; 43(5): 816-22, 1989 May 15.
Article
em En
| MEDLINE
| ID: mdl-2497073
CL26 murine colon carcinoma cells express urokinase-type plasminogen activator (u-PA) mRNA and activity after transfection with the activated c-Ha-ras-I (EJ-ras) oncogene cloned from the EJ bladder carcinoma. PA activity and mRNA in control cells transfected with the non-mutated c-Ha-ras-I (CO-ras) gene remained negative. Ras mRNA was detected in EJ-ras- and CO-ras-transfected cells, but not in untransfected or pSV2-neo-transfected cells. These results indicate that u-PA biosynthesis can be modulated by EJ-Ha-ras-dependent pathways of signal transduction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Ativadores de Plasminogênio
/
Ativador de Plasminogênio Tipo Uroquinase
/
Genes ras
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Neoplasias do Colo
/
Precursores Enzimáticos
Limite:
Animals
Idioma:
En
Revista:
Int J Cancer
Ano de publicação:
1989
Tipo de documento:
Article
País de publicação:
Estados Unidos