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Antioxidant effects of lipophilic tea polyphenols on diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in rats.
Zhou, Fan; Shen, Ting; Duan, Ting; Xu, Yu-Ying; Khor, Soo Chin; Li, Jin; Ge, Juan; Zheng, Yi-Fan; Hsu, Stephen; DE Stefano, Jamie; Yang, Jun; Xu, Li-Hong; Zhu, Xin-Qiang.
Afiliação
  • Zhou F; Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, P.R. China Minhang District Center for Disease Control and Prevention of Shanghai, Shanghai, P.R. China.
  • Shen T; Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, P.R. China Xihu District Center for Disease Control and Prevention, Hangzhou, Zhejiang, P.R. China.
  • Duan T; Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, P.R. China.
  • Xu YY; Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, P.R. China.
  • Khor SC; Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, P.R. China.
  • Li J; Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, P.R. China.
  • Ge J; Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, P.R. China.
  • Zheng YF; Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, P.R. China.
  • Hsu S; Department of Oral Biology and Maxillofacial Pathology, Georgia Health Sciences University, Augusta, GA, U.S.A.
  • DE Stefano J; Department of Periodontics, Georgia Regents University, Augusta, GA, U.S.A.
  • Yang J; Department of Toxicology, Hangzhou Normal University School of Public Health, Hangzhou, Zhejiang, P.R. China.
  • Xu LH; Department of Biochemistry and Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China zhuxq@zju.edu.cn xulihong@zju.edu.cn.
  • Zhu XQ; Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, P.R. China zhuxq@zju.edu.cn xulihong@zju.edu.cn.
In Vivo ; 28(4): 495-503, 2014.
Article em En | MEDLINE | ID: mdl-24982215
ABSTRACT

BACKGROUND:

The purpose of the present study was to compare the antioxidant potential of lipophilic tea polyphenols (LTP) against the one of naturally-occurring water-soluble green tea polyphenols (GTP) in a two-stage model of diethylnitrosamine (DEN)/phenobarbital (PB)-induced hepatocarcinogenesis in Sprague-Dawley rats. MATERIALS AND

METHODS:

GTP/LTP was given 5-times weekly by oral gavage with tea polyphenols equivalent to 0-, 40- and 400-mg/kg of body weight/day. GTP/LTP treatment was started 2 weeks prior to the initiation of DEN and continued for 30 weeks.

RESULTS:

Histopathological and electron microscopic examination of liver tissue confirmed the protective effect of LTP on DEN/PB-induced liver damage and pre-carcinogenesis. LTP treatment significantly increased total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) activity in liver tissues. Immunohistochemical detection of cellular nuclear factor erythroid-2-related factor-2 (Nrf2) and peroxiredoxin-6 (P6) indicated a down-regulation in Nrf2 and up-regulation of P6 expression in the liver of LTP-supplemented rats.

CONCLUSION:

The present study provides evidence for the first time, that LTP exerts significant antioxidant effects on DEN/PB-induced liver damage and hepatocarcinogenesis through elevating T-AOC levels, enhancing GSH-Px activity and inducing P6 expression in rat liver tissues.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenobarbital / Chá / Carcinógenos / Transformação Celular Neoplásica / Dietilnitrosamina / Polifenóis / Antioxidantes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: In Vivo Assunto da revista: NEOPLASIAS Ano de publicação: 2014 Tipo de documento: Article
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenobarbital / Chá / Carcinógenos / Transformação Celular Neoplásica / Dietilnitrosamina / Polifenóis / Antioxidantes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: In Vivo Assunto da revista: NEOPLASIAS Ano de publicação: 2014 Tipo de documento: Article