Use of a two-way non-rebreathing valve to simplify the measurement of twitch mouth pressure using an inspiratory pressure trigger and the establishment of an optimal trigger threshold for healthy subjects and COPD patients.

OBJECTIVE: Controlled twitch mouth pressure (Tw Pmo) via the use of a two-way non-rebreathing valve is a new method to assess diaphragm contractility. The optimal trigger threshold was confirmed. DESIGN: We sought to determine the optimal trigger threshold for 17 healthy subjects (29±4 years) and 17 COPD patients (64±10 years). The Tw Pmo, twitch oesophageal pressure (Tw Pes) and twitch transdiaphragmatic pressure (Tw Pdi) in response to phrenic nerve stimulation were measured using an inspiratory pressure trigger at -1, -2, -3, -4, -5 and -6 cmH2O. RESULTS: The lung volume did not change during triggering at different trigger thresholds using a two-way non-rebreathing valve. The highest correlation between Tw Pmo and Tw Pes in healthy subjects and COPD patients occurred for a -2 cmH2O trigger threshold (r=0.939 and r=0.869, P<0.0001). The narrowest limits of agreement for Tw Pmo and Tw Pes both occurred at -2 cmH2O in healthy subjects, with a bias (range) of -0.4 cmH2O (-1.85 to 1.41), and in COPD patients, with a bias (range) of 0.1 6cmH2O (-1.36-1.67). CONCLUSIONS: We conclude that the measurement of Tw Pmo using a two-way non-rebreathing valve is of clinical value to investigate the suspected diaphragm contractility. The highest trigger threshold for clinical applications was -2 cmH2O.