Bicyclic tetrapeptides as potent HDAC inhibitors: effect of aliphatic loop position and hydrophobicity on inhibitory activity.

Islam, Md Nurul; Islam, Md Shahidul; Hoque, Md Ashraful; Kato, Tamaki; Nishino, Norikazu; Ito, Akihiro; Yoshida, Minoru

Islam, Md Nurul; Islam, Md Shahidul; Hoque, Md Ashraful; Kato, Tamaki; Nishino, Norikazu; Ito, Akihiro; Yoshida, Minoru.

Afiliação

Islam MN; Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan; Department of Chemistry, Faculty of Science, University of Rajshahi, Rajshahi 6205, Bangladesh. Electronic address: mnurulchem@gmail.com.
Islam MS; Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan; Department of Chemistry, Faculty of Science, University of Rajshahi, Rajshahi 6205, Bangladesh.
Hoque MA; Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan; Department of Biochemistry and Molecular Biology, Faculty of Science, University of Rajshahi, Rajshahi 6205, Bangladesh.
Kato T; Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan.
Nishino N; Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan.
Ito A; Chemical Genetics Laboratory/Chemical Genomics Research Group, RIKEN Advanced Science Institute, Saitama 351-0198, Japan.
Yoshida M; Chemical Genetics Laboratory/Chemical Genomics Research Group, RIKEN Advanced Science Institute, Saitama 351-0198, Japan.

Bioorg Med Chem ; 22(15): 3862-70, 2014 Aug 01.

Article em En | MEDLINE | ID: mdl-25022972

Assuntos

Inibidores de Histona Desacetilases/química; Oligopeptídeos/química; Peptídeos Cíclicos/química; Inibidores de Histona Desacetilases/síntese química; Inibidores de Histona Desacetilases/metabolismo; Histona Desacetilases/química; Histona Desacetilases/metabolismo; Humanos; Interações Hidrofóbicas e Hidrofílicas; Peptídeos e Proteínas de Sinalização Intercelular; Oligopeptídeos/síntese química; Peptídeos/química; Peptídeos Cíclicos/síntese química; Peptídeos Cíclicos/metabolismo; Ligação Proteica

Palavras-chave

Aliphatic loop position; Bicyclic tetrapeptides; Histone deacetylase inhibitors; Ring-closing metathesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Peptídeos Cíclicos / Inibidores de Histona Desacetilases Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Reino Unido

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