Genetic variations of bile salt transporters.
Drug Discov Today Technol
; 12: e55-67, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-25027376
ABSTRACT
Bile salt transporters directly or indirectly influence biological processes through physicochemical or signalling properties of bile salts. The coordinated action of uptake and efflux transporters in polarized epithelial cells of the liver, biliary tree, small intestine and kidney determine bile salt concentrations in different compartments of the body. Genetic variations of bile salt transporters lead to clinical relevant phenotypes of varying severity ranging from a predisposition for drug-induced liver injury to rapidly progressing end-stage liver disease. This review focuses on the impact of genetic variations of bile salt transporters including BSEP, NTCP, ASBT and OSTα/ß and discusses approaches for transporter analysis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Variação Genética
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Ácidos e Sais Biliares
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Transportadores de Cassetes de Ligação de ATP
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Transportadores de Ânions Orgânicos Dependentes de Sódio
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Simportadores
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Discov Today Technol
Ano de publicação:
2014
Tipo de documento:
Article