In vitro and in vivo evaluation of benzamidomethyl-benzylpenicillinate (FI7303). A new 'repository' form.
Chemotherapy
; 24(6): 338-42, 1978.
Article
em En
| MEDLINE
| ID: mdl-250463
ABSTRACT
A new type of hydrolyzable ester of penicillin G, benzamidomethyl benzylpenicillinate (FI 7303), was studied for the antibacterial activity and kinetics of absorption in comparison with DBED-penicillin G. FI 7303 resulted to be a good repository form of penicillin G, slowly eliminated in mouse, dog and man. It exerted a remarkable therapeutic activity in mice infected with Staphylococcus aureus even when administered 26 h before infection. The protective effect in mice was more prolonged than that of DBED-penicillin G, in agreement with the longer persistence of significant blood levels.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Penicilina G
/
Infecções Estafilocócicas
/
Bactérias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chemotherapy
Ano de publicação:
1978
Tipo de documento:
Article