Cyclical dehydration-induced renal injury and Mesoamerican nephropathy: as sweet by any other name?
Kidney Int
; 86(2): 226-9, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-25079017
ABSTRACT
Severe cyclical dehydration induces chronic renal injury in rodents. This effect is attenuated by global fructokinase deficiency, suggesting possible roles for fructokinase and fructose metabolism in mediating or promoting dehydration-induced injury. Clinical and pathological similarities between this injury model and endemic Mesoamerican nephropathy (MeN) have fueled speculation that dehydration-induced injury and MeN may share common mechanistic underpinnings involving fructokinase that can be targeted to mitigate disease development, progression, and/or severity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desidratação
/
Frutoquinases
/
Rim
Limite:
Animals
Idioma:
En
Revista:
Kidney Int
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos