Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity.

Mehndiratta, Samir; Hsieh, Yi-Ling; Liu, Yi-Min; Wang, Amber Weiching; Lee, Hsueh-Yun; Liang, Lung-Yu; Kumar, Sunil; Teng, Che-Ming; Yang, Chia-Ron; Liou, Jing-Ping

Mehndiratta, Samir; Hsieh, Yi-Ling; Liu, Yi-Min; Wang, Amber Weiching; Lee, Hsueh-Yun; Liang, Lung-Yu; Kumar, Sunil; Teng, Che-Ming; Yang, Chia-Ron; Liou, Jing-Ping.

Afiliação

Mehndiratta S; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Hsieh YL; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Liu YM; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Wang AW; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Lee HY; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Liang LY; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Kumar S; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Teng CM; Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yang CR; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: cryang@ntu.edu.tw.
Liou JP; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan. Electronic address: jpl@tmu.edu.tw.

Eur J Med Chem ; 85: 468-79, 2014 Oct 06.

Article em En | MEDLINE | ID: mdl-25113875

Assuntos

Anti-Inflamatórios/química; Anti-Inflamatórios/farmacologia; Inibidores de Histona Desacetilases/química; Inibidores de Histona Desacetilases/farmacologia; Indóis/química; Indóis/farmacologia; Animais; Anti-Inflamatórios/uso terapêutico; Sobrevivência Celular/efeitos dos fármacos; Edema/tratamento farmacológico; Células HeLa; Inibidores de Histona Desacetilases/uso terapêutico; Humanos; Indóis/uso terapêutico; Ratos

Palavras-chave

Anti-inflammatory activity; Histone deacetylase inhibitors; Indole

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Histona Desacetilases / Indóis / Anti-Inflamatórios Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Taiwan País de publicação: França

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