Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.

Rakheja, Dinesh; Chen, Kenneth S; Liu, Yangjian; Shukla, Abhay A; Schmid, Vanessa; Chang, Tsung-Cheng; Khokhar, Shama; Wickiser, Jonathan E; Karandikar, Nitin J; Malter, James S; Mendell, Joshua T; Amatruda, James F

Rakheja, Dinesh; Chen, Kenneth S; Liu, Yangjian; Shukla, Abhay A; Schmid, Vanessa; Chang, Tsung-Cheng; Khokhar, Shama; Wickiser, Jonathan E; Karandikar, Nitin J; Malter, James S; Mendell, Joshua T; Amatruda, James F.

Afiliação

Rakheja D; 1] Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [2] Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [3] Division of Pathology and Laboratory Medicine, Children's Medical Center, Dallas, Texas 75
Chen KS; 1] Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [2] Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [3] Gill Center for Cancer and Blood Disorders, Children's Medical Center, Dallas, Tex
Liu Y; 1] Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [2].
Shukla AA; 1] Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [2] Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Schmid V; Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Chang TC; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Khokhar S; Division of Pathology and Laboratory Medicine, Children's Medical Center, Dallas, Texas 75235, USA.
Wickiser JE; 1] Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [2] Gill Center for Cancer and Blood Disorders, Children's Medical Center, Dallas, Texas 75235, USA.
Karandikar NJ; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Malter JS; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Mendell JT; 1] Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [2] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Amatruda JF; 1] Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [2] Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [3] Department of Molecular Biology, University of Texas Southwestern Me

Nat Commun ; 2: 4802, 2014 Sep 05.

Article em En | MEDLINE | ID: mdl-25190313

Assuntos

RNA Helicases DEAD-box/genética; Neoplasias Renais/genética; MicroRNAs/metabolismo; Ribonuclease III/genética; Tumor de Wilms/genética; Criança; Pré-Escolar; Estudos de Coortes; Feminino; Células HEK293; Humanos; Lactente; Masculino; Mutação de Sentido Incorreto; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Análise de Sequência de DNA

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tumor de Wilms / MicroRNAs / Ribonuclease III / RNA Helicases DEAD-box / Neoplasias Renais Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Reino Unido

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google