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The relationship among HOXA10, estrogen receptor α, progesterone receptor, and progesterone receptor B proteins in rectosigmoid endometriosis: a tissue microarray study.
Zanatta, Alysson; Pereira, Ricardo Mendes Alves; Rocha, André Monteiro da; Cogliati, Bruno; Baracat, Edmund Chada; Taylor, Hugh S; Motta, Eduardo Leme Alves da; Serafini, Paulo Cesar.
Afiliação
  • Zanatta A; Department of Gynecology, São Paulo University School of Medicine, Sao Paulo, Brazil alysson.zanatta@gmail.com.
  • Pereira RM; Endometriosis Center, Santa Joana Hospital, Sao Paulo, Brazil.
  • Rocha AM; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI.
  • Cogliati B; Department of Molecular and Morphologic Sciences, São Paulo University School of Zootechny and Veterinary Medicine, Sao Paulo, Brazil.
  • Baracat EC; Department of Gynecology, São Paulo University School of Medicine, Sao Paulo, Brazil.
  • Taylor HS; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
  • Motta EL; Department of Gynecology, São Paulo Federal University School of Medicine, Sao Paulo, Brazil.
  • Serafini PC; Department of Gynecology, São Paulo University School of Medicine, Sao Paulo, Brazil.
Reprod Sci ; 22(1): 31-7, 2015 Jan.
Article em En | MEDLINE | ID: mdl-25217304
ABSTRACT

BACKGROUND:

Very few studies have evaluated the expression of homeobox A10 (HOXA10) and steroid (estrogen and progesterone) receptors exclusively in deep endometriosis. Conclusions drawn from studies evaluating peritoneal and ovarian endometriosis are usually generalized to explain the pathogenesis of the disease as a whole. We aimed to evaluate the expression of HOXA10, estrogen receptor α (ER-α), progesterone receptor (PR), and PR-B in rectosigmoid endometriosis (RE), a typical model of deep disease.

METHODS:

We used RE samples from 18 consecutive patients to construct tissue microarray blocks. Nine patients each were operated during the proliferative and secretory phases of the menstrual cycle. We quantified the expressions of proteins by immunohistochemistry using the modified Allred score.

RESULT:

The HOXA10 was expressed in the stroma of nodules during the secretory phase in 5 of the 18 patients. Expression of ER-α (in 16 of 18 patients), PR (in 17 of 18 patients), and PR-B (17 of 18 patients) was moderate to strong in the glands and stroma of nodules during both phases. Expression of both PR (P = .023) and PR-B (P = .024) was significantly greater during the secretory phase.

CONCLUSION:

The HOXA10 is expressed in RE, where it likely imparts the de novo identity of endometriotic lesions. The ER-α, PR, and PR-B are strongly expressed in RE, which differs from previous studies investigating peritoneal and ovarian lesions. This suggests different routes of pathogenesis for each of the 3 types of endometriosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Retais / Doenças do Colo Sigmoide / Receptores de Progesterona / Proteínas de Homeodomínio / Receptor alfa de Estrogênio / Análise Serial de Tecidos / Endometriose / Endométrio Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans Idioma: En Revista: Reprod Sci Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Retais / Doenças do Colo Sigmoide / Receptores de Progesterona / Proteínas de Homeodomínio / Receptor alfa de Estrogênio / Análise Serial de Tecidos / Endometriose / Endométrio Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans Idioma: En Revista: Reprod Sci Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil