The effect on melanoma risk of genes previously associated with telomere length.
J Natl Cancer Inst
; 106(10)2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25231748
ABSTRACT
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Telômero
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Mutação em Linhagem Germinativa
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Polimorfismo de Nucleotídeo Único
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Proteínas de Ligação a Telômeros
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Melanoma
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do norte
/
Asia
/
Europa
/
Oceania
Idioma:
En
Revista:
J Natl Cancer Inst
Ano de publicação:
2014
Tipo de documento:
Article