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A novel open-source drug-delivery system that allows for first-of-kind simulation of nonadherence to pharmacological interventions in animal disease models.
Thomson, Kyle E; White, H Steve.
Afiliação
  • Thomson KE; Bioengineering Dept, University of Utah, Salt Lake City, UT, USA.
  • White HS; Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA. Electronic address: steve.white@hsc.utah.edu.
J Neurosci Methods ; 238: 105-11, 2014 Dec 30.
Article em En | MEDLINE | ID: mdl-25256646
ABSTRACT

BACKGROUND:

Nonadherence to a physician-prescribed therapeutic intervention is a costly, dangerous, and sometimes fatal concern in healthcare. To date, the study of nonadherence has been constrained to clinical studies. The novel approach described herein allows for the preclinical study of nonadherence in etiologically relevant disease animal model systems. NEW

METHOD:

The method herein describes a novel computer-automated pellet delivery system which allows for the study of nonadherence in animals. This system described herein allows for tight experimenter control of treatment using a drug-in-food protocol. Food-restricted animals receive either medicated or unmedicated pellets, designed to mimic either "taking" or "missing" a drug.

RESULTS:

The system described permits the distribution of medicated or unmedicated food pellets on an experimenter-defined feeding schedule. The flexibility of this system permits the delivery of drug according to the known pharmacokinetics of investigational drugs. COMPARISON WITH OTHER

METHODS:

Current clinical adherence research relies on medication-event monitoring system (MEMS) tracking caps, which allows clinicians to directly monitor patient adherence. However, correlating the effects of nonadherence to efficacy still relies on the accuracy of patient journals.

CONCLUSION:

This system allows for the design of studies to address the impact of nonadherence in an etiologically relevant animal model. Given methodological and ethical concerns of designing clinical studies of nonadherence, animal studies are critical to better understand medication adherence. While the system described was designed to measure the impact of nonadherence on seizure control, it is clear that the utility of this system extends beyond epilepsy to include other disease states.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Software / Sistemas de Liberação de Medicamentos / Modelos Animais de Doenças / Adesão à Medicação / Distribuidores Automáticos de Alimentos Tipo de estudo: Guideline Aspecto: Ethics Limite: Animals Idioma: En Revista: J Neurosci Methods Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: HOLANDA / HOLLAND / NETHERLANDS / NL / PAISES BAJOS / THE NETHERLANDS

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Software / Sistemas de Liberação de Medicamentos / Modelos Animais de Doenças / Adesão à Medicação / Distribuidores Automáticos de Alimentos Tipo de estudo: Guideline Aspecto: Ethics Limite: Animals Idioma: En Revista: J Neurosci Methods Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: HOLANDA / HOLLAND / NETHERLANDS / NL / PAISES BAJOS / THE NETHERLANDS