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TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
Shameer, Sanu; Logan-Klumpler, Flora J; Vinson, Florence; Cottret, Ludovic; Merlet, Benjamin; Achcar, Fiona; Boshart, Michael; Berriman, Matthew; Breitling, Rainer; Bringaud, Frédéric; Bütikofer, Peter; Cattanach, Amy M; Bannerman-Chukualim, Bridget; Creek, Darren J; Crouch, Kathryn; de Koning, Harry P; Denise, Hubert; Ebikeme, Charles; Fairlamb, Alan H; Ferguson, Michael A J; Ginger, Michael L; Hertz-Fowler, Christiane; Kerkhoven, Eduard J; Mäser, Pascal; Michels, Paul A M; Nayak, Archana; Nes, David W; Nolan, Derek P; Olsen, Christian; Silva-Franco, Fatima; Smith, Terry K; Taylor, Martin C; Tielens, Aloysius G M; Urbaniak, Michael D; van Hellemond, Jaap J; Vincent, Isabel M; Wilkinson, Shane R; Wyllie, Susan; Opperdoes, Fred R; Barrett, Michael P; Jourdan, Fabien.
Afiliação
  • Shameer S; Institut National de la Recherche Agronomique (INRA), UMR1331, TOXALIM (Research Centre in Food Toxicology), Université de Toulouse, Toulouse, France.
  • Logan-Klumpler FJ; The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Vinson F; Institut National de la Recherche Agronomique (INRA), UMR1331, TOXALIM (Research Centre in Food Toxicology), Université de Toulouse, Toulouse, France.
  • Cottret L; Institut National de la Recherche Agronomique (INRA), UMR441, Laboratoire des Interactions Plantes-Microorganismes (LIPM), Auzeville, France.
  • Merlet B; Institut National de la Recherche Agronomique (INRA), UMR1331, TOXALIM (Research Centre in Food Toxicology), Université de Toulouse, Toulouse, France.
  • Achcar F; University of Glasgow, Glasgow, Scotland, G12 8QQ, UK.
  • Boshart M; Ludwig-Maximilians-Universität München, Biocenter, 82152-Martinsried, Germany.
  • Berriman M; The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Breitling R; Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester, UK.
  • Bringaud F; CNRS, Bordeaux, 33076, France.
  • Bütikofer P; University of Bern, Bern, CH-3012, Switzerland.
  • Cattanach AM; University of Glasgow, Glasgow, Scotland, G12 8QQ, UK.
  • Bannerman-Chukualim B; The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Creek DJ; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia.
  • Crouch K; University of Glasgow, Glasgow, Scotland, G12 8QQ, UK.
  • de Koning HP; University of Glasgow, Glasgow, Scotland, G12 8QQ, UK.
  • Denise H; European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, CB10 1SD, UK.
  • Ebikeme C; ISSC, UNESCO, F-75732 CEDEX 15, Paris, France.
  • Fairlamb AH; University of Dundee, Dundee, Scotland, DD1 4HN, UK.
  • Ferguson MA; University of Dundee, Dundee, Scotland, DD1 4HN, UK.
  • Ginger ML; Divisionof Biomedical and Life Sciences, Lancaster University, Bailrigg, Lancaster, LA1 4YG, UK.
  • Hertz-Fowler C; University of Liverpool, Liverpool, Merseyside L69 3BX, UK.
  • Kerkhoven EJ; Chalmers University of Technology, Kemivägen 10, 412 96, Göteborg, Sweden.
  • Mäser P; Swiss Tropical and Public Health Institute, Socinstr. 57, Basel 4051, Switzerland.
  • Michels PA; University of Edinburgh, Mayfield Road, Edinburgh EH9 3JU, UK.
  • Nayak A; University of Glasgow, Glasgow, Scotland, G12 8QQ, UK.
  • Nes DW; Texas Tech University, Lubbock, TX, USA.
  • Nolan DP; Trinity College Dublin, Dublin 2, Ireland.
  • Olsen C; Biomatters Inc. 60 Park Place, Suite 2100, Newark, NJ, USA.
  • Silva-Franco F; University of Liverpool, Liverpool, Merseyside L69 3BX, UK.
  • Smith TK; University of St Andrews, St Andrews, Scotland, KY16 9ST, UK.
  • Taylor MC; LSHTM, London, WC1E 7HT, UK.
  • Tielens AG; Utrecht University, Utrecht, 3508 TD, The Netherlands Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
  • Urbaniak MD; Divisionof Biomedical and Life Sciences, Lancaster University, Bailrigg, Lancaster, LA1 4YG, UK.
  • van Hellemond JJ; Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
  • Vincent IM; University of Glasgow, Glasgow, Scotland, G12 8QQ, UK.
  • Wilkinson SR; Queen Mary University of London, London E1 4NS, UK.
  • Wyllie S; University of Dundee, Dundee, Scotland, DD1 4HN, UK.
  • Opperdoes FR; University of Louvain, Brussels, B-1200, Belgium.
  • Barrett MP; University of Glasgow, Glasgow, Scotland, G12 8QQ, UK Fabien.Jourdan@toulouse.inra.fr.
  • Jourdan F; Institut National de la Recherche Agronomique (INRA), UMR1331, TOXALIM (Research Centre in Food Toxicology), Université de Toulouse, Toulouse, France Fabien.Jourdan@toulouse.inra.fr.
Nucleic Acids Res ; 43(Database issue): D637-44, 2015 Jan.
Article em En | MEDLINE | ID: mdl-25300491
ABSTRACT
The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions. Our understanding of individual metabolic networks is increasing as we learn more about the enzymes that are active in particular cells under particular conditions and as technologies advance to allow detailed measurements of the cellular metabolome. Metabolic network databases are of increasing importance in allowing us to contextualise data sets emerging from transcriptomic, proteomic and metabolomic experiments. Here we present a dynamic database, TrypanoCyc (http//www.metexplore.fr/trypanocyc/), which describes the generic and condition-specific metabolic network of Trypanosoma brucei, a parasitic protozoan responsible for human and animal African trypanosomiasis. In addition to enabling navigation through the BioCyc-based TrypanoCyc interface, we have also implemented a network-based representation of the information through MetExplore, yielding a novel environment in which to visualise the metabolism of this important parasite.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trypanosoma brucei brucei / Bases de Dados de Compostos Químicos Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trypanosoma brucei brucei / Bases de Dados de Compostos Químicos Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: França