A comprehensive model for correcting RNFL readings of varying signal strengths in cirrus optical coherence tomography.
Invest Ophthalmol Vis Sci
; 55(11): 7297-302, 2014 Oct 16.
Article
em En
| MEDLINE
| ID: mdl-25324287
ABSTRACT
PURPOSE:
To develop a model for the Cirrus HD-OCT that allows for the comparison of retinal nerve fiber layer (RNFL) thickness measurements with dissimilar signal strengths (SS) and accounts for test-retest variability.METHODS:
Retinal nerve fiber layers were obtained in normals using the Cirrus optic disc cube 200 × 200 protocol during a single encounter. Five RNFL scans were obtained with a SS of 9 or 10. Diffusion lens filters were used to degrade SS to obtain five scans at each SS group of 7 or 8, 5 or 6, and 3 or 4. The relationship between average RNFL thickness and SS was established, and an equation was developed to allow for adjustment of an RNFL measurement had it been a SS of 7. Intravisit interclass correlation coefficient (ICC) and coefficient of variation (CV) parameter estimates for each SS group were calculated. Repeatability and upper tolerance limit were calculated as 1.96 × â2 × within-subject standard deviation (Sw) and 1.645 × â2 × Sw, respectively.RESULTS:
There was a linear relationship between average RNFL and SS. RNFLadj = RNFL - 1.03*SS + 7.21 allows for the adjustment of RNFL readings to the same SS. Interclass correlation coefficients and CVs were good for all measurements down to SS of 3 or 4. Repeatability and upper tolerance limit were 5.24 and 4.40 µm, respectively.CONCLUSIONS:
Our model adjusts RNFL readings based on SS and includes an upper tolerance limit of 5 µm. If validated, this model could improve the detection of real RNFL changes. Further study to validate this model should be performed before widespread use is adopted.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Disco Óptico
/
Células Ganglionares da Retina
/
Algoritmos
/
Doenças do Nervo Óptico
/
Tomografia de Coerência Óptica
/
Modelos Teóricos
/
Fibras Nervosas
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Invest Ophthalmol Vis Sci
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos