Current status of antisense RNA-mediated gene regulation in Listeria monocytogenes.
Front Cell Infect Microbiol
; 4: 135, 2014.
Article
em En
| MEDLINE
| ID: mdl-25325017
ABSTRACT
Listeria monocytogenes is a Gram-positive human-pathogen bacterium that served as an experimental model for investigating fundamental processes of adaptive immunity and virulence. Recent novel technologies allowed the identification of several hundred non-coding RNAs (ncRNAs) in the Listeria genome and provided insight into an unexpected complex transcriptional machinery. In this review, we discuss ncRNAs that are encoded on the opposite strand of the target gene and are therefore termed antisense RNAs (asRNAs). We highlight mechanistic and functional concepts of asRNAs in L. monocytogenes and put these in context of asRNAs in other bacteria. Understanding asRNAs will further broaden our knowledge of RNA-mediated gene regulation and may provide targets for diagnostic and antimicrobial development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Bacteriano
/
Regulação Bacteriana da Expressão Gênica
/
RNA Antissenso
/
Listeria monocytogenes
Idioma:
En
Revista:
Front Cell Infect Microbiol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Alemanha