Implementation of quantitative and systems pharmacology in large pharma.
CPT Pharmacometrics Syst Pharmacol
; 3: e142, 2014 Oct 22.
Article
em En
| MEDLINE
| ID: mdl-25338195
ABSTRACT
Quantitative and systems pharmacology concepts and tools are the foundation of the model-informed drug development paradigm at Merck for integrating knowledge, enabling decisions, and enhancing submissions. Rigorous prioritization of modeling and simulation activities has enabled key drug development decisions and led to a high return on investment through significant cost avoidance. Critical factors for the successful implementation, examples on impact on decision making with associated return of investment, and drivers for continued success are discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
CPT Pharmacometrics Syst Pharmacol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos