Radiolabeled 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine--I. Synthesis and purification.
Int J Rad Appl Instrum A
; 40(1): 27-31, 1989.
Article
em En
| MEDLINE
| ID: mdl-2540120
ABSTRACT
The purpose of this investigation was to synthesize and purify radiolabeled 9- or 10-monoiodostearyl carnitine for potential use as a perfusion and metabolic imaging agent for the heart. Oleic acid was iodinated via a free radical addition reaction of HI across the double bond to give 9- or 10-monoiodostearic acid which in turn was esterified with carnitine. The identity of 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine was determined using nuclear magnetic resonance (NMR), infrared (i.r.), ultraviolet (u.v.), and mass spectroscopy. The purity of the fatty acid and carnitine ester was established by thin layer chromatography. 9- or 10-Monoiodo[125I]stearic acid and 9- or 10-monoiodo[125I]stearyl carnitine were synthesized via the isotopic exchange of 125I for cold iodine bonded to 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Esteáricos
/
Carnitina
/
Radioisótopos do Iodo
/
Marcação por Isótopo
Idioma:
En
Revista:
Int J Rad Appl Instrum A
Assunto da revista:
MEDICINA NUCLEAR
/
RADIOLOGIA
Ano de publicação:
1989
Tipo de documento:
Article
País de publicação:
ENGLAND
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ESCOCIA
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GB
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GREAT BRITAIN
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INGLATERRA
/
REINO UNIDO
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SCOTLAND
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UK
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UNITED KINGDOM