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The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease.
Peng, Xinxia; Alföldi, Jessica; Gori, Kevin; Eisfeld, Amie J; Tyler, Scott R; Tisoncik-Go, Jennifer; Brawand, David; Law, G Lynn; Skunca, Nives; Hatta, Masato; Gasper, David J; Kelly, Sara M; Chang, Jean; Thomas, Matthew J; Johnson, Jeremy; Berlin, Aaron M; Lara, Marcia; Russell, Pamela; Swofford, Ross; Turner-Maier, Jason; Young, Sarah; Hourlier, Thibaut; Aken, Bronwen; Searle, Steve; Sun, Xingshen; Yi, Yaling; Suresh, M; Tumpey, Terrence M; Siepel, Adam; Wisely, Samantha M; Dessimoz, Christophe; Kawaoka, Yoshihiro; Birren, Bruce W; Lindblad-Toh, Kerstin; Di Palma, Federica; Engelhardt, John F; Palermo, Robert E; Katze, Michael G.
Afiliação
  • Peng X; Department of Microbiology, University of Washington, Seattle, Washington, USA.
  • Alföldi J; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Gori K; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK.
  • Eisfeld AJ; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA.
  • Tyler SR; 1] Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. . [2] Molecular and Cellular Biology Program, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
  • Tisoncik-Go J; Department of Microbiology, University of Washington, Seattle, Washington, USA.
  • Brawand D; 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] MRC Functional Genomics Unit, University of Oxford, xford, UK (D.B.); Biogen Idec, Cambridge, Massachusetts, USA (M.L.); Division of Biology, California Institute of Technology, Pasadena, California, USA (P.R.); Vertebrate and
  • Law GL; Department of Microbiology, University of Washington, Seattle, Washington, USA.
  • Skunca N; 1] Department of Computer Science, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland. [2] Swiss Institute of Bioinformatics, Zurich, Switzerland.
  • Hatta M; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA.
  • Gasper DJ; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA.
  • Kelly SM; Department of Microbiology, University of Washington, Seattle, Washington, USA.
  • Chang J; Department of Microbiology, University of Washington, Seattle, Washington, USA.
  • Thomas MJ; Department of Microbiology, University of Washington, Seattle, Washington, USA.
  • Johnson J; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Berlin AM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Lara M; 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] MRC Functional Genomics Unit, University of Oxford, xford, UK (D.B.); Biogen Idec, Cambridge, Massachusetts, USA (M.L.); Division of Biology, California Institute of Technology, Pasadena, California, USA (P.R.); Vertebrate and
  • Russell P; 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] MRC Functional Genomics Unit, University of Oxford, xford, UK (D.B.); Biogen Idec, Cambridge, Massachusetts, USA (M.L.); Division of Biology, California Institute of Technology, Pasadena, California, USA (P.R.); Vertebrate and
  • Swofford R; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Turner-Maier J; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Young S; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Hourlier T; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
  • Aken B; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
  • Searle S; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
  • Sun X; Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. .
  • Yi Y; Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. .
  • Suresh M; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA.
  • Tumpey TM; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Siepel A; Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA.
  • Wisely SM; Department of Wildlife Ecology and Conservation, University of Florida, Gainesville, Florida, USA.
  • Dessimoz C; 1] European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK. [2] Department of Genetics, Evolution and Environment, University College London, London, UK. [3] Department of Computer Science, University College London, London, UK.
  • Kawaoka Y; 1] Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA. [2] ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan. [3] Division of Virology, Department of Microbiology and Immunology, In
  • Birren BW; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Lindblad-Toh K; 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
  • Di Palma F; 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] MRC Functional Genomics Unit, University of Oxford, xford, UK (D.B.); Biogen Idec, Cambridge, Massachusetts, USA (M.L.); Division of Biology, California Institute of Technology, Pasadena, California, USA (P.R.); Vertebrate and
  • Engelhardt JF; 1] Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. . [2] Center for Gene Therapy, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
  • Palermo RE; Department of Microbiology, University of Washington, Seattle, Washington, USA.
  • Katze MG; 1] Department of Microbiology, University of Washington, Seattle, Washington, USA. [2] Washington National Primate Research Center, Seattle, Washington, USA.
Nat Biotechnol ; 32(12): 1250-5, 2014 Dec.
Article em En | MEDLINE | ID: mdl-25402615
ABSTRACT
The domestic ferret (Mustela putorius furo) is an important animal model for multiple human respiratory diseases. It is considered the 'gold standard' for modeling human influenza virus infection and transmission. Here we describe the 2.41 Gb draft genome assembly of the domestic ferret, constituting 2.28 Gb of sequence plus gaps. We annotated 19,910 protein-coding genes on this assembly using RNA-seq data from 21 ferret tissues. We characterized the ferret host response to two influenza virus infections by RNA-seq analysis of 42 ferret samples from influenza time-course data and showed distinct signatures in ferret trachea and lung tissues specific to 1918 or 2009 human pandemic influenza virus infections. Using microarray data from 16 ferret samples reflecting cystic fibrosis disease progression, we showed that transcriptional changes in the CFTR-knockout ferret lung reflect pathways of early disease that cannot be readily studied in human infants with cystic fibrosis disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma / Análise de Sequência de DNA / Influenza Humana / Furões Limite: Animals / Humans Idioma: En Revista: Nat Biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma / Análise de Sequência de DNA / Influenza Humana / Furões Limite: Animals / Humans Idioma: En Revista: Nat Biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos