Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining.

Kobayashi, S; Kasaishi, Y; Nakada, S; Takagi, T; Era, S; Motegi, A; Chiu, R K; Takeda, S; Hirota, K

Kobayashi, S; Kasaishi, Y; Nakada, S; Takagi, T; Era, S; Motegi, A; Chiu, R K; Takeda, S; Hirota, K.

Afiliação

Kobayashi S; Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kasaishi Y; Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Nakada S; Center of Integrated Medical Research, School of Medicine, Keio University, Tokyo, Japan.
Takagi T; Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Tokyo, Japan.
Era S; Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Motegi A; Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Chiu RK; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Takeda S; Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hirota K; 1] Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Kyoto, Japan [2] Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Tokyo, Japan.

Oncogene ; 34(33): 4403-11, 2015 Aug 13.

Article em En | MEDLINE | ID: mdl-25417706

Assuntos

Reparo do DNA por Junção de Extremidades/genética; Proteínas de Ligação a DNA/genética; Recombinação Homóloga/genética; Rad51 Recombinase/genética; Antígenos Nucleares/genética; Linhagem Celular Tumoral; Reparo do DNA/genética; Replicação do DNA/genética; Células HCT116; Humanos; Autoantígeno Ku; Enzimas de Conjugação de Ubiquitina/genética; Ubiquitina-Proteína Ligases/genética; Ubiquitinação/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a DNA / Rad51 Recombinase / Reparo do DNA por Junção de Extremidades / Recombinação Homóloga Limite: Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido

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