Epstein-Barr virus-transformed human B lymphocytes endocytose autologous and heterologous red blood cells.
Int Arch Allergy Appl Immunol
; 88(3): 312-6, 1989.
Article
em En
| MEDLINE
| ID: mdl-2542165
ABSTRACT
Epstein-Barr virus (EBV)-transformed B lymphocytes, either isolated from a patient with EBV-induced infectious mononucleosis or obtained by in vitro infection of B lymphocytes of donors in different clinical conditions, have been tested for the ability to endocytose particulate forms of antigens, such as human, sheep or mouse red blood cells. By light and electron microscopy, it has been found that EBV-transformed B cells are able to bind and internalize human autologous and allogeneic erythrocytes, as well as sheep and mouse erythrocytes, independent of the specificity of the secreted immunoglobulins. The ability of EBV-transformed B lymphocytes to endocytose and process particulate forms of autoantigens during infectious mononucleosis might have a role both in the production of heterophile antibodies and in EBV-induced autoimmunity.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Grupos Sanguíneos
/
Linfócitos B
/
Transformação Celular Viral
/
Antígenos Heterófilos
/
Endocitose
/
Eritrócitos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int Arch Allergy Appl Immunol
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Itália