Targeting cell-intrinsic and cell-extrinsic mechanisms of intravasation in invasive breast cancer.
Sci Signal
; 7(353): pe28, 2014 Nov 25.
Article
em En
| MEDLINE
| ID: mdl-25429075
The survival of breast cancer patients with metastatic disease has not markedly improved over recent decades, highlighting the need to better understand this process. In this issue of Science Signaling, Pignatelli et al. used freshly obtained invasive ductal carcinoma cells from patients to demonstrate the need for high abundance of the invasive isoform of the Mena protein (Mena(INV)) in cancer cells and colony-stimulating factor 1 (CSF-1)-mediated paracrine signaling in macrophages for efficient transendothelial migration and metastasis formation in all clinical breast cancer subtypes. Furthermore, the triple negative and HER2(+) subtypes, but not the ERPR(+)/HER2(-) subtype, had high CSF-1 receptor (CSF-1R) abundance and also partially used autocrine CSF-1/CSF-1R signaling for invasion. These data establish Mena(INV), CSF-1/CSF-1R, and macrophages as potential therapeutic targets for most human breast cancers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Biomarcadores Tumorais
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Carcinoma Ductal de Mama
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Migração Transendotelial e Transepitelial
/
Macrófagos
/
Proteínas dos Microfilamentos
/
Invasividade Neoplásica
/
Proteínas de Neoplasias
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Sci Signal
Assunto da revista:
CIENCIA
/
FISIOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Bélgica
País de publicação:
Estados Unidos