Orally administered tolfenamic acid inhibits leukotriene synthesis in isolated human peripheral polymorphonuclear leukocytes.
Agents Actions
; 28(1-2): 83-8, 1989 Aug.
Article
em En
| MEDLINE
| ID: mdl-2551152
ABSTRACT
Special interest has been focused on the development of dual inhibitors of the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid metabolism. In contrast to other classic NSAIDs, some fenamates in clinically achievable concentrations have been shown to inhibit synthesis of 5-lipoxygenase products in vitro. In the present work, we studied the effect of orally administered tolfenamic acid (600 mg) on Ca ionophore A 23187 -induced leukotriene synthesis in isolated human polymorphonuclear leukocytes. Leukotriene production was reduced in all 14 subjects studied, the mean inhibition of LTB4 synthesis being 16 +/- 3% and that of LTC4 33 +/ 7%. The inhibition correlated positively with serum acid concentrations. We suggest that inhibition of leukotriene synthesis is an additional mechanism of the anti-inflammatory, antimigraine and antidysmenorrhoeic effects of tolfenamic acid, and a possible explanation for its rare gastric and bronchoconstrictive side-effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
SRS-A
/
Anti-Inflamatórios não Esteroides
/
Leucotrieno B4
/
Ortoaminobenzoatos
/
Neutrófilos
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Agents Actions
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Finlândia