Characterization of the autoimmune response against the nerve tissue S100ß in patients with type 1 diabetes.
Clin Exp Immunol
; 180(2): 207-17, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25516468
ABSTRACT
Type 1 diabetes results from destruction of insulin-producing beta cells in pancreatic islets and is characterized by islet cell autoimmunity. Autoreactivity against non-beta cell-specific antigens has also been reported, including targeting of the calcium-binding protein S100ß. In preclinical models, reactivity of this type is a key component of the early development of insulitis. To examine the nature of this response in type 1 diabetes, we identified naturally processed and presented peptide epitopes derived from S100ß, determined their affinity for the human leucocyte antigen (HLA)-DRB1*0401 molecule and studied T cell responses in patients, together with healthy donors. We found that S100ß reactivity, characterized by interferon (IFN)-γ secretion, is a characteristic of type 1 diabetes of varying duration. Our results confirm S100ß as a target of the cellular autoimmune response in type 1 diabetes with the identification of new peptide epitopes targeted during the development of the disease, and support the preclinical findings that autoreactivity against non-beta cell-specific autoantigens may have a role in type 1 diabetes pathogenesis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Epitopos de Linfócito T
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Diabetes Mellitus Tipo 1
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Subunidade beta da Proteína Ligante de Cálcio S100
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Imunidade Celular
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Exp Immunol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Espanha