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Uncovering potential 'herbal probiotics' in Juzen-taiho-to through the study of associated bacterial populations.
Montenegro, Diego; Kalpana, Kriti; Chrissian, Christine; Sharma, Ashutosh; Takaoka, Anna; Iacovidou, Maria; Soll, Clifford E; Aminova, Olga; Heguy, Adriana; Cohen, Lisa; Shen, Steven; Kawamura, Akira.
Afiliação
  • Montenegro D; Department of Chemistry, Hunter College of CUNY, 695 Park Avenue, New York, NY 10065, USA.
  • Kalpana K; Department of Chemistry, Hunter College of CUNY, 695 Park Avenue, New York, NY 10065, USA.
  • Chrissian C; Department of Chemistry, Hunter College of CUNY, 695 Park Avenue, New York, NY 10065, USA.
  • Sharma A; Department of Chemistry, Hunter College of CUNY, 695 Park Avenue, New York, NY 10065, USA.
  • Takaoka A; Department of Chemistry, Hunter College of CUNY, 695 Park Avenue, New York, NY 10065, USA.
  • Iacovidou M; Department of Chemistry, Hunter College of CUNY, 695 Park Avenue, New York, NY 10065, USA.
  • Soll CE; Department of Chemistry, Hunter College of CUNY, 695 Park Avenue, New York, NY 10065, USA.
  • Aminova O; Genome Technology Center, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016, USA.
  • Heguy A; Genome Technology Center, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016, USA.
  • Cohen L; Genome Technology Center, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016, USA.
  • Shen S; Genome Technology Center, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, Center for Health Informatics and Bioinformatics, NYU School of Medicine, 227 East 30th Street, New York, NY 10016, USA.
  • Kawamura A; Department of Chemistry, Hunter College of CUNY, 695 Park Avenue, New York, NY 10065, USA.
Bioorg Med Chem Lett ; 25(3): 466-9, 2015 Feb 01.
Article em En | MEDLINE | ID: mdl-25547935
Juzen-taiho-to (JTT) is an immune-boosting formulation of ten medicinal herbs. It is used clinically in East Asia to boost the human immune functions. The active factors in JTT have not been clarified. But, existing evidence suggests that lipopolysaccharide (LPS)-like factors contribute to the activity. To examine this possibility, JTT was subjected to a series of analyses, including high resolution mass spectrometry, which suggested the presence of structural variants of LPS. This finding opened a possibility that JTT contains immune-boosting bacteria. As the first step to characterize the bacteria in JTT, 16S ribosomal RNA sequencing was carried out for Angelica sinensis (dried root), one of the most potent immunostimulatory herbs in JTT. The sequencing revealed a total of 519 bacteria genera in A. sinensis. The most abundant genus was Rahnella, which is widely distributed in water and plants. The abundance of Rahnella appeared to correlate with the immunostimulatory activity of A. sinensis. In conclusion, the current study provided new pieces of evidence supporting the emerging theory of bacterial contribution in immune-boosting herbs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Probióticos Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Probióticos Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido