Analysis of serum cytokine levels in larynx squamous cell carcinoma and dysplasia patients.
Iran J Immunol
; 11(4): 259-68, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25549593
BACKGROUND: Although the imbalance of cytokines in Head and Neck Squamous Cell Carcinoma (HNSCC) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. OBJECTIVE: To determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. METHODS: Seventeen newly diagnosed, untreated larynx squamous cell carcinoma (SCC) and six laryngeal dysplasia patients as well as 22 healthy controls were analyzed for circulating cytokines. A flowcytometry Th1/Th2 cytokine array kit was used to quantitatively measure Interleukin-2 (IL-2), IL-4, IL-6, IL-10, Tumor Necrosis Factor-α (TNF-α) and Interferon-γ (IFN-γ) levels. Additionally, IL-8 levels were determined through ELISA. RESULTS: IL-6, IL-8 and IL-10 were determined to be statistically increased in SCC patients (p<0.05). IL-8 and IL-10 levels were also higher in SCC patients than dysplasia patients (p<0.05). Additionally, IL-6 and IL-10 were all found to be markedly increased in dysplasia patients compared with controls (p<0.05). CONCLUSION: Our results demonstrate an imbalance of IL-6 and IL-10 not only in HNSCC but also in laryngeal dysplasia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
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Carcinoma de Células Escamosas
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Doenças da Laringe
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Neoplasias Laríngeas
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Citocinas
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Células Th2
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Laringe
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Iran J Immunol
Ano de publicação:
2014
Tipo de documento:
Article
País de publicação:
Irã