Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1).

Arai, Yuki; Endo, Satoshi; Miyagi, Namiki; Abe, Naohito; Miura, Takeshi; Nishinaka, Toru; Terada, Tomoyuki; Oyama, Masayoshi; Goda, Hiroaki; El-Kabbani, Ossama; Hara, Akira; Matsunaga, Toshiyuki; Ikari, Akira

Arai, Yuki; Endo, Satoshi; Miyagi, Namiki; Abe, Naohito; Miura, Takeshi; Nishinaka, Toru; Terada, Tomoyuki; Oyama, Masayoshi; Goda, Hiroaki; El-Kabbani, Ossama; Hara, Akira; Matsunaga, Toshiyuki; Ikari, Akira.

Afiliação

Arai Y; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Endo S; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan. Electronic address: sendo@gifu-pu.ac.jp.
Miyagi N; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Abe N; Laboratory of Pharmacognosy, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Miura T; Laboratory of Biochemistry, Faculty of Pharmacy, Osaka Ohtani University, Osaka 584-8540, Japan.
Nishinaka T; Laboratory of Biochemistry, Faculty of Pharmacy, Osaka Ohtani University, Osaka 584-8540, Japan.
Terada T; Laboratory of Biochemistry, Faculty of Pharmacy, Osaka Ohtani University, Osaka 584-8540, Japan.
Oyama M; Laboratory of Pharmacognosy, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Goda H; School of Pharmacy, Showa University, Tokyo 142-8555, Japan.
El-Kabbani O; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Hara A; Faculty of Engineering, Gifu University, Gifu 501-1193, Japan.
Matsunaga T; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Ikari A; Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan.

Fitoterapia ; 101: 51-6, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25549925

Assuntos

Oxirredutases do Álcool/antagonistas & inibidores; Flavonoides/química; Humanos; Luteolina/química; Simulação de Acoplamento Molecular; Estrutura Molecular; Proteínas Recombinantes; Relação Estrutura-Atividade

Palavras-chave

(S)-(+)-1,2,3,4-Tetrahydro-1-naphthol (PubChem CID: 7058029); Acacetin (PubChem CID: 5280442); Apigenin (PubChem CID: 5280443); CBR1; Carbonyl reductase; Chrysin (PubChem CID: 5281607); Flavonoid; Isatin (PubChem CID: 7054); Kaempferide (PubChem CID: 5281666); Kaempferol (PubChem CID: 5280863); Luteolin; Luteolin (PubChem CID: 5280445); Quercetin (PubChem CID: 5280343); Quercitrin (PubChem CID: 5280459); Structureactivity relationship

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Oxirredutases do Álcool Limite: Humans Idioma: En Revista: Fitoterapia Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Japão

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