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The minimal clinically important difference of the Control of Allergic Rhinitis and Asthma Test (CARAT): cross-cultural validation and relation with pollen counts.
van der Leeuw, Sander; van der Molen, Thys; Dekhuijzen, P N Richard; Fonseca, Joao A; van Gemert, Frederik A; Gerth van Wijk, Roy; Kocks, Janwillem W H; Oosterom, Helma; Riemersma, Roland A; Tsiligianni, Ioanna G; de Weger, Letty A; Oude Elberink, Joanne N G; Flokstra-de Blok, Bertine M J.
Afiliação
  • van der Leeuw S; 1] Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands [2] GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • van der Molen T; 1] Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands [2] GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Dekhuijzen PN; Department of Pulmonology, University Medical Center St Radboud, Nijmegen, The Netherlands.
  • Fonseca JA; Department of Health Information and Decision Sciences, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
  • van Gemert FA; 1] Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands [2] GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Gerth van Wijk R; Department of Internal Medicine-Allergology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Kocks JW; 1] Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands [2] GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Oosterom H; 1] Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands [2] GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Riemersma RA; 1] Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands [2] GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Tsiligianni IG; 1] Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands [2] GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • de Weger LA; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
  • Oude Elberink JN; 1] GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands [2] Department of Allergology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Flokstra-de Blok BM; 1] Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands [2] GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
NPJ Prim Care Respir Med ; 25: 14107, 2015 Jan 08.
Article em En | MEDLINE | ID: mdl-25569880
ABSTRACT

BACKGROUND:

The Control of Allergic Rhinitis and Asthma Test (CARAT) monitors control of asthma and allergic rhinitis.

AIMS:

To determine the CARAT's minimal clinically important difference (MCID) and to evaluate the psychometric properties of the Dutch CARAT.

METHODS:

CARAT was applied in three measurements at 1-month intervals. Patients diagnosed with asthma and/or rhinitis were approached. MCID was evaluated using Global Rating of Change (GRC) and standard error of measurement (s.e.m.). Cronbach's alpha was used to evaluate internal consistency. Spearman's correlation coefficients were calculated between CARAT, the Asthma Control Questionnaire (ACQ5) and the Visual Analog Scale (VAS) on airway symptoms to determine construct and longitudinal validity. Test-retest reliability was evaluated with intra-class correlation coefficient (ICC). Changes in pollen counts were compared with delta CARAT and ACQ5 scores.

RESULTS:

A total of 92 patients were included. The MCID of the CARAT was 3.50 based on GRC scores; the s.e.m. was 2.83. Cronbach's alpha was 0.82. Correlation coefficients between CARAT and ACQ5 and VAS questions ranged from 0.64 to 0.76 (P < 0.01). Longitudinally, correlation coefficients between delta CARAT scores and delta ACQ5 and VAS scores ranged from 0.41 to 0.67 (P < 0.01). Test-retest reliability showed an ICC of 0.81 (P < 0.01) and 0.80 (P < 0.01). Correlations with pollen counts were higher for CARAT than for ACQ5.

CONCLUSIONS:

This is the first investigation of the MCID of the CARAT. The CARAT uses a whole-point scale, which suggests that the MCID is 4 points. The CARAT is a valid and reliable tool that is also applicable in the Dutch population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Rinite Alérgica Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: NPJ Prim Care Respir Med Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Rinite Alérgica Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: NPJ Prim Care Respir Med Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Holanda