Thr175-phosphorylated tau induces pathologic fibril formation via GSK3ß-mediated phosphorylation of Thr231 in vitro.

Moszczynski, Alexander J; Gohar, May; Volkening, Kathryn; Leystra-Lantz, Cheryl; Strong, Wendy; Strong, Michael J

Moszczynski, Alexander J; Gohar, May; Volkening, Kathryn; Leystra-Lantz, Cheryl; Strong, Wendy; Strong, Michael J.

Afiliação

Moszczynski AJ; Graduate Program in Neuroscience, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Gohar M; Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Volkening K; Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Department of Clinical Neurological Sciences, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Leystra-Lantz C; Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Strong W; Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Strong MJ; Graduate Program in Neuroscience, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Department of Clinical Neurological Sciences, Schulich Sch

Neurobiol Aging ; 36(3): 1590-9, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25573097

Assuntos

Quinase 3 da Glicogênio Sintase/metabolismo; Neurofibrilas/patologia; Proteínas tau/metabolismo; Motivos de Aminoácidos; Esclerose Lateral Amiotrófica/genética; Esclerose Lateral Amiotrófica/patologia; Esclerose Lateral Amiotrófica/terapia; Morte Celular/genética; Células Cultivadas; Biologia Computacional; Técnicas de Silenciamento de Genes; Quinase 3 da Glicogênio Sintase/antagonistas & inibidores; Glicogênio Sintase Quinase 3 beta; Células HEK293; Humanos; Fosforilação; RNA Interferente Pequeno/genética; Tauopatias/genética; Tauopatias/patologia; Tauopatias/terapia; Treonina/metabolismo; Proteínas tau/química

Palavras-chave

Amyotrophic lateral sclerosis; Glycogen synthase kinase 3 ß; Microtubule-associated protein tau; Tauopathy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas tau / Quinase 3 da Glicogênio Sintase / Neurofibrilas Limite: Humans Idioma: En Revista: Neurobiol Aging Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos

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