Your browser doesn't support javascript.
loading
Faster in vivo clearance of human embryonic kidney than Chinese hamster ovary cell derived protein: Role of glycan mediated clearance.
Wang, Mengmeng; Ishino, Tetsuya; Joyce, Alison; Tam, Amy; Duan, Weili; Lin, Laura; Somers, William S; Kriz, Ronald; O'Hara, Denise M.
Afiliação
  • Wang M; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Andover, MA 01810, USA. Electronic address: Mengmeng.Wang@pfizer.com.
  • Ishino T; Department of Global Biotherapeutics Technologies, Pfizer Inc., Cambridge, MA 02140, USA.
  • Joyce A; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Andover, MA 01810, USA.
  • Tam A; Department of Global Biotherapeutics Technologies, Pfizer Inc., Cambridge, MA 02140, USA.
  • Duan W; Department of Global Biotherapeutics Technologies, Pfizer Inc., Cambridge, MA 02140, USA.
  • Lin L; Department of Global Biotherapeutics Technologies, Pfizer Inc., Cambridge, MA 02140, USA.
  • Somers WS; Department of Global Biotherapeutics Technologies, Pfizer Inc., Cambridge, MA 02140, USA.
  • Kriz R; Department of Global Biotherapeutics Technologies, Pfizer Inc., Cambridge, MA 02140, USA.
  • O'Hara DM; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Andover, MA 01810, USA.
J Biosci Bioeng ; 119(6): 657-60, 2015 Jun.
Article em En | MEDLINE | ID: mdl-25575972
ABSTRACT
This investigation used in vivo and in vitro tools to study pharmacokinetics and glycosylation of two monomeric antibodies produced either transiently by HEK293 cells or stably by Chinese hamster ovary cells, and demonstrated that higher in vivo clearance of human embryonic kidney antibody was due to higher glycosylation, thus higher mannose receptor mediated uptake.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicosilação / Mananas / Anticorpos Limite: Animals / Humans Idioma: En Revista: J Biosci Bioeng Assunto da revista: ENGENHARIA BIOMEDICA / MICROBIOLOGIA Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicosilação / Mananas / Anticorpos Limite: Animals / Humans Idioma: En Revista: J Biosci Bioeng Assunto da revista: ENGENHARIA BIOMEDICA / MICROBIOLOGIA Ano de publicação: 2015 Tipo de documento: Article