Multidrug resistance-reversal effects of resin glycosides from Dichondra repens.

Song, Wei-Bin; Wang, Wen-Qiong; Zhang, Shu-Wei; Xuan, Li-Jiang

Song, Wei-Bin; Wang, Wen-Qiong; Zhang, Shu-Wei; Xuan, Li-Jiang.

Afiliação

Song WB; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
Wang WQ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
Zhang SW; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
Xuan LJ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China. Electronic address: ljxuan@mail.shcnc.ac.cn.

Bioorg Med Chem Lett ; 25(4): 795-8, 2015 Feb 15.

Article em En | MEDLINE | ID: mdl-25597010

ABSTRACT

ABSTRACT

Investigation of hydrophobic extract of Dichondra repens (Convolvulaceae) led to the isolation of three new resin glycosides dichondrins A-C (1-3), and three known resin glycosides cus-1, cus-2, and cuse 3. All the isolated resin glycosides with an acyclic core were evaluated for their multidrug resistance reversal activities, and the combined use of these compounds at a concentration of 25µM increased the cytotoxicity of vincristine by 1.03-1.78-fold.

Assuntos

Glicosídeos/química; Glicosídeos/farmacologia; Poaceae/química; Resinas Vegetais/química; Resinas Vegetais/farmacologia; Sequência de Carboidratos; Resistência a Múltiplos Medicamentos; Resistencia a Medicamentos Antineoplásicos; Sinergismo Farmacológico; Humanos; Células KB; Dados de Sequência Molecular; Folhas de Planta/química; Vincristina/farmacologia

Palavras-chave

Dichondra repens; Multidrug-resistance (MDR) reversal activity; Resin glycoside acids

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resinas Vegetais / Glicosídeos / Poaceae Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article

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