The effect of thyroid hormones on the membrane adenylate cyclase activity in sickle red blood cells in vitro.
Ital J Biochem
; 38(5): 324-9, 1989.
Article
em En
| MEDLINE
| ID: mdl-2561120
ABSTRACT
A comparative study of thyroid hormone responsive membrane adenylate cyclase activity has been carried out on normal (Hb-AA) and sickle cell (Hb-SS) subjects. Thyroid hormones (T3 and T4) and selected analogues (TRIAC and DLT) enhanced adenylate cyclase activity in Hb-AA membranes. The interaction of Hb-SS membranes with the hormones and analogues was not significant except for T3 which moderately stimulated Hb-SS membrane adenylate cyclase. We suggest that circulating irreversibly sickled cells, in view of their membrane phospholipid defect, probably contribute to the low response of membrane adenylate cyclase to effector stimulation.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiroxina
/
Tri-Iodotironina
/
Adenilil Ciclases
/
Membrana Eritrocítica
/
Anemia Falciforme
Limite:
Humans
Idioma:
En
Revista:
Ital J Biochem
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Nigéria