Spontaneous regression of infantile dural-based non-Langerhans cell histiocytosis after surgery: case report.
J Neurosurg Pediatr
; 15(4): 372-9, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25634822
ABSTRACT
The authors report the case of a large left occipital mass lesion in an 8-month-old boy who presented with seizure. Neuroimaging demonstrated an approximately 5-cm extraaxial tumor, and the patient underwent partial resection. The tumor was strongly attached to the tentorium and falx. In the postoperative course the residual lesion regressed spontaneously, and after 5 years only a slight residual tumor remained along the tentorium. Histopathological examination of the tumor revealed non-Langerhans cell histiocytosis (non-LCH). However, the tumor was not diagnosed as juvenile xanthogranuloma (JXG) because it lacked Touton giant cells. Hence, the authors described this lesion as a fibroxanthogranuloma. Most intracraniospinal non-LCHs have been reported as JXG; however, several cases of xanthomatous tumors with histopathological features resembling those of JXG have been described as fibrous xanthoma, xanthoma, fibroxanthoma, and xanthogranuloma. Among JXG and the xanthomatous tumors, a review of the literature revealed several cases of dural-based tumors; these dural-based tumors have had favorable courses, including the case described in this report. In addition, the patient in the present case experienced spontaneous regression of the residual tumor. The authors report this unique case and review the literature on isolated intracraniospinal non-LCHs, especially in cases of dural-based lesion.
Palavras-chave
EMA = epithelial membrane antigen; GFAP = glial fibrillary acidic protein; JXG = juvenile xanthogranuloma; LCA = leukocyte common antigen; LCH = Langerhans cell histiocytosis; NFP = neurofilament protein; XG = xanthogranuloma; dural-based lesion; infant; non-Langerhans cell histiocytosis; oncology; spontaneous regression; α-SMA = αsmooth muscle actin
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Biomarcadores Tumorais
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Transtornos Histiocíticos Malignos
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Neoplasia Residual
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Dura-Máter
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Regressão Neoplásica Espontânea
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Humans
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Infant
/
Male
Idioma:
En
Revista:
J Neurosurg Pediatr
Assunto da revista:
NEUROCIRURGIA
/
PEDIATRIA
Ano de publicação:
2015
Tipo de documento:
Article