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Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6.
Bhela, Siddheshvar; Kempsell, Christine; Manohar, Monali; Dominguez-Villar, Margarita; Griffin, Russell; Bhatt, Pooja; Kivisakk-Webb, Pia; Fuhlbrigge, Robert; Kupper, Thomas; Weiner, Howard; Baecher-Allan, Clare.
Afiliação
  • Bhela S; Center for Neurologic Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; and.
  • Kempsell C; Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Manohar M; Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Dominguez-Villar M; Center for Neurologic Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; and.
  • Griffin R; Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Bhatt P; Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Kivisakk-Webb P; Center for Neurologic Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; and.
  • Fuhlbrigge R; Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Kupper T; Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Weiner H; Center for Neurologic Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; and.
  • Baecher-Allan C; Center for Neurologic Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; and Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115 callan@rics.bwh.harvard.edu.
J Immunol ; 194(5): 2180-9, 2015 Mar 01.
Article em En | MEDLINE | ID: mdl-25637022
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos HLA-DR / Interleucina-6 / Linfócitos T Reguladores / Esclerose Múltipla Recidivante-Remitente / Granzimas / Subunidade alfa de Receptor de Interleucina-2 / Subunidade alfa de Receptor de Interleucina-7 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Immunol Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos HLA-DR / Interleucina-6 / Linfócitos T Reguladores / Esclerose Múltipla Recidivante-Remitente / Granzimas / Subunidade alfa de Receptor de Interleucina-2 / Subunidade alfa de Receptor de Interleucina-7 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Immunol Ano de publicação: 2015 Tipo de documento: Article