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Micropillar substrates: a tool for studying cell mechanobiology.
Gupta, Mukund; Kocgozlu, Leyla; Sarangi, Bibhu Ranjan; Margadant, Felix; Ashraf, Mohammed; Ladoux, Benoit.
Afiliação
  • Gupta M; Mechanobiology Institute, National University of Singapore, Singapore.
  • Kocgozlu L; Mechanobiology Institute, National University of Singapore, Singapore.
  • Sarangi BR; Institut Jacques Monod (IJM), CNRS UMR 7592 & Université Paris Diderot, Paris, France.
  • Margadant F; Mechanobiology Institute, National University of Singapore, Singapore.
  • Ashraf M; Mechanobiology Institute, National University of Singapore, Singapore.
  • Ladoux B; Mechanobiology Institute, National University of Singapore, Singapore; Institut Jacques Monod (IJM), CNRS UMR 7592 & Université Paris Diderot, Paris, France.
Methods Cell Biol ; 125: 289-308, 2015.
Article em En | MEDLINE | ID: mdl-25640435
Increasing evidence has shown that mechanical cues from the environment play an important role in cell biology. Mechanotransduction or the study of how cells can sense these mechanical cues, and respond to them, is an active field of research. However, it is still not clear how cells sense and respond to mechanical cues. Thus, new tools are being rapidly developed to quantitatively study cell mechanobiology. Particularly, force measurement tools such as micropillar substrates have provided new insights into the underlying mechanisms of mechanosensing. In this chapter, we provide detailed protocol for fabrication, characterization, functionalization, and use of the micropillar substrates.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biofísica / Mecanotransdução Celular Limite: Animals Idioma: En Revista: Methods Cell Biol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Singapura País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biofísica / Mecanotransdução Celular Limite: Animals Idioma: En Revista: Methods Cell Biol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Singapura País de publicação: Estados Unidos