Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system.
RSC Adv
; 5(12): 8753-8756, 2015 Jan 08.
Article
em En
| MEDLINE
| ID: mdl-25642326
ABSTRACT
We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the nanoscale fibrous shell formed by self-assembly of peptide amphiphiles offers a high surface to volume ratio that is ideal for targeting. The synthesised microparticles have a 60-fold higher cytotoxicity against MDA-MB-231 breast cancer cells compared to non-targeting particles.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
RSC Adv
Ano de publicação:
2015
Tipo de documento:
Article