Diagnostic value of immature myeloid information in early-onset bacterial infection in term and preterm neonates.
Klin Padiatr
; 227(2): 66-71, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25650870
ABSTRACT
BACKGROUND:
For quick detection of neonatal early-onset bacterial infection (EOBI) pro-inflammatory cytokines like Interleukin-6 (IL-6) and Interleukin-8 (IL-8) in combiantion with C-reactive Protein (CRP) have been used. Automated determination of immature myeloid information (IMI) seems to be an additional useful tool in the diagnosis of NBI.OBJECTIVE:
To compare the diagnostic value of IMI, I/T-Ratio, plasma IL-6 and IL-8 levels and CRP in term and preterm neonates at time of clinical suspicion of EOBI. PATIENTS ANDMETHODS:
31 preterm and 123 term neonates with clinical and serological signs of EOBI were analysed. 91 preterm and 159 term neonates with risk factors but without proven EOBI served as non-infected controls.RESULTS:
Neonates with EOBI showed significantly elevated IMI levels at time of first clinical suspicion of EOBI (Preterm 1 028/µL (38-8 759) vs. 289/µL (6-3 126); Term 1 268/µL (48-14 035) vs. 856/µL (19-5 735); p<0.05 respectively). I/T-Ratio, IL-6, IL-8 and CRP values were significantly higher in preterm and term neonates with EOBI (p<0.05). Sensitivity of IMI at a cut-off level of 650/µL was 84.2% [95%-CI 74.0-91.6%] in preterm and 65.4% [95%-CI 56.8-73.3%] in term infants. Specificity was 66.7% [95%-CI 47.1-82.7%] and 53.9% [95%-CI 43.8-63.7%], respectively. Combination of different infection parameters improved sensitivity up to 93.5% and specificity up to 98.9%.CONCLUSION:
The diagnostic value of IMI in diagnosing EOBI in preterm and term neonates is not comparable to IL-6, IL-8 and CRP. Combination of IMI-Channel with IL-6, IL-8 or CRP improves their sensitivity, specificity and predictive value.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
/
Infecções Oportunistas
/
Mediadores da Inflamação
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Células Progenitoras Mieloides
/
Doenças do Prematuro
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Female
/
Humans
/
Male
/
Newborn
País/Região como assunto:
Europa
Idioma:
En
Revista:
Klin Padiatr
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Alemanha