Dextrin and poly(acrylic acid)-based biodegradable, non-cytotoxic, chemically cross-linked hydrogel for sustained release of ornidazole and ciprofloxacin.
ACS Appl Mater Interfaces
; 7(8): 4791-803, 2015 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-25654747
ABSTRACT
Herein, novel biodegradable, stimulus-responsive, chemically cross-linked and porous hydrogel has been synthesized to evaluate its applicability as an efficient carrier for sustained release of ornidazole and ciprofloxacin. The cross-linked hydrogel (c-Dxt/pAA) has been developed from dextrin and poly(acrylic acid) using N,N'-methylene bis(acrylamide) cross-linker via Michael-type addition reaction. With the variation of reaction parameters, various c-Dxt/pAA hydrogels have been synthesized to optimize the best one. c-Dxt/pAA hydrogel has been characterized using various physicochemical characterization techniques. The hydrogel demonstrates significant pH and temperature sensitivity. Gel characteristics and gel kinetics have been performed through the measurement of rheological parameters. The hydrogel shows noncytotoxic behavior toward human mesenchymal stem cells. Biodegradation study predicts that c-Dxt/pAA is degradable in nature. The in vitro release of ornidazole and ciprofloxacin suggests that the hydrogel released both the drugs in a controlled manner with extensive stability up to 3 months. The results suggest that c-Dxt/pAA is probably a promising candidate for controlled release of ornidazole and ciprofloxacin.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ornidazol
/
Resinas Acrílicas
/
Portadores de Fármacos
/
Ciprofloxacina
/
Hidrogéis
/
Dextrinas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
ACS Appl Mater Interfaces
Assunto da revista:
BIOTECNOLOGIA
/
ENGENHARIA BIOMEDICA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Índia