A 3-month oral vitamin D supplementation marginally improves diastolic blood pressure in Saudi patients with type 2 diabetes mellitus.
Int J Clin Exp Med
; 7(12): 5421-8, 2014.
Article
em En
| MEDLINE
| ID: mdl-25664051
ABSTRACT
The aim of the current study was to determine whether oral cholecalciferol (45000 IU) per week for the 2 months and once on the 3rd month could translate to full vitamin D status correction and improved metabolic profile among patients with suboptimal vitamin D status. A total of 248 Saudi patients with T2DM were screened for vitamin D deficiency. Two hundred out of the 248 patients had suboptimal vitamin D levels, and were randomly assigned to receive vitamin D oral supplementation (45000 IU/week for 2 months and a single 45000 IU in the last month) or placebo for 3 months. Anthropometrics and fasting blood samples were taken at baseline and after 3 months. Serum glucose, HBA1c and lipid profile were measured routinely and serum 25-OH vitamin D using ELISA. More than half of the subjects (59.8%) were vitamin D deficient at screening. Both groups had significant improvements in vitamin D levels after 3 months, with most of the treatment group achieving status correction. In the treatment group, a significant improvement in the diastolic blood pressure was observed after 3 months (P = 0.021), while the rest of the variables were comparable. Vitamin D supplementation of 45000 IU/week for 2 months and once on the 3rd month was able to improve vitamin D status among vitamin D deficient T2DM patients and marginally improve diastolic blood pressure.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
Idioma:
En
Revista:
Int J Clin Exp Med
Ano de publicação:
2014
Tipo de documento:
Article