Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa.

O'Brien, Kevin T; Noto, Joseph G; Nichols-O'Neill, Luke; Perez, Lark J

O'Brien, Kevin T; Noto, Joseph G; Nichols-O'Neill, Luke; Perez, Lark J.

Afiliação

O'Brien KT; Department of Chemistry and Biochemistry, Rowan University , 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Noto JG; Department of Chemistry and Biochemistry, Rowan University , 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Nichols-O'Neill L; Department of Chemistry and Biochemistry, Rowan University , 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Perez LJ; Department of Chemistry and Biochemistry, Rowan University , 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.

ACS Med Chem Lett ; 6(2): 162-7, 2015 Feb 12.

Article em En | MEDLINE | ID: mdl-25699144

RESUMO

Antagonism of quorum sensing represents a promising new antivirulence approach for the treatment of bacterial infection. The development of a novel series of non-natural irreversible antagonists of P. aeruginosa LasR is described. The lead compounds identified (25 and 28) display potent LasR antagonist activity and inhibit expression of the P. aeruginosa virulence factors pyocyanin and biofilm formation in PAO1 and PA14.

Palavras-chave

Pseudomonas aeruginosa; antivirulence; biofilm inhibition; quorum sensing; structure−activity relationship

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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