Cyclic adenosine 5'-diphosphoribose (cADPR) mimics used as molecular probes in cell signaling.
Chem Rec
; 15(2): 511-23, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25707449
ABSTRACT
Cyclic adenosine 5'-diphosphate ribose (cADPR) is a second messenger in the Ca(2+) signaling pathway. To elucidate its molecular mechanism in calcium release, a series of cADPR analogues with modification on ribose, nucleobase, and pyrophosphate have been investigated. Among them, the analogue with the modification of the northern ribose by ether linkage substitution (cIDPRE) exhibits membrane-permeate Ca(2+) agonistic activity in intact HeLa cells, human T cells, mouse cardiac myocytes and neurosecretory PC12 cell lines; thus, cIDPRE and coumarin-caged cIDPRE are valuable probes to investigate the cADPR-mediated Ca(2+) signal pathway.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sondas Moleculares
/
Cálcio
/
Sinalização do Cálcio
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Miócitos Cardíacos
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ADP-Ribose Cíclica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Rec
Assunto da revista:
QUIMICA
Ano de publicação:
2015
Tipo de documento:
Article