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T2 shine-through phenomena in diffusion-weighted MR imaging of lumbar discs after oxygen-ozone discolysis: a randomized, double-blind trial with steroid and O2-O3 discolysis versus steroid only.
Perri, Marco; Grattacaso, Giuseppe; di Tunno, Valeria; Marsecano, Claudia; Gennarelli, Antonio; Michelini, Giulia; Splendiani, Alessandra; Di Cesare, Ernesto; Masciocchi, Carlo; Gallucci, Massimo.
Afiliação
  • Perri M; Department of Biotechnological and Applied Clinical Sciences, Division of Radiology, University of L'Aquila, 67100, L'Aquila, Italy. marco-perri@tiscali.it.
  • Grattacaso G; Department of Biotechnological and Applied Clinical Sciences, Division of Radiology, University of L'Aquila, 67100, L'Aquila, Italy. Giuseppe.grattacaso@hotmail.it.
  • di Tunno V; Department of Biotechnological and Applied Clinical Sciences, Division of Radiology, University of L'Aquila, 67100, L'Aquila, Italy. valeria.ditunno@yahoo.it.
  • Marsecano C; Department of Biotechnological and Applied Clinical Sciences, Division of Radiology, University of L'Aquila, 67100, L'Aquila, Italy. claudia.marsecano@gmail.com.
  • Gennarelli A; Department of Biotechnological and Applied Clinical Sciences, Division of Radiology, University of L'Aquila, 67100, L'Aquila, Italy. antoniogennarelli@alice.it.
  • Michelini G; Department of Biotechnological and Applied Clinical Sciences, Division of Radiology, University of L'Aquila, 67100, L'Aquila, Italy. giulia.mik@libero.it.
  • Splendiani A; Department of Biotechnological and Applied Clinical Sciences, Division of Neuroradiology, University of L'Aquila, 67100, L'Aquila, Italy. alessandra.splendiani@univaq.it.
  • Di Cesare E; Department of Biotechnological and Applied Clinical Sciences, Division of Radiology, University of L'Aquila, 67100, L'Aquila, Italy. Ernesto.dicesre@cc.univaq.it.
  • Masciocchi C; Department of Biotechnological and Applied Clinical Sciences, Division of Radiology, University of L'Aquila, 67100, L'Aquila, Italy. carlo.masciocchi@cc.univaq.it.
  • Gallucci M; Department of Biotechnological and Applied Clinical Sciences, Division of Neuroradiology, University of L'Aquila, 67100, L'Aquila, Italy. Massimo.gallucci@cc.univaq.it.
Radiol Med ; 120(10): 941-50, 2015 Oct.
Article em En | MEDLINE | ID: mdl-25743238
PURPOSE: To evaluate the discal morpho-structural changes as predictive sign in the clinical outcome after Ozone Therapy in lumbar disc herniation using the T2 shine-through effect in DWI. METHODS: One hundred and fifty-four patients suffering from lumbosciatica (89 men and 65 women; range 23-62 years) were included in previous MR study performed with FSE-T2 and T2-fat, SE-T1 and DWI sequences and were randomly assigned to two groups. Seventy-seven patients (Control Group) underwent conservative treatment with intraforaminal injection of steroid and anesthetic. The remaining 77 patients (Study Group) underwent the same treatment with the addiction of oxygen-ozone (O2-O3). During the coming 6 months, an MRI follow-up with the same sequences was performed. An intervertebral disc volumetric analysis (IDVA), DWI signal score and post treatment clinical outcome evaluation were performed for an assessment of hernia reduction. χ (2) test, Student's t test and analysis of covariance were used for comparison of variables. RESULTS: In the Study Group, 58 over 77 patients had a successful outcome (Responders). In the Responders group, DWI T2 shine-through effect was present during MRI follow-up and in particular in 53 of 77 patients in the 6 months of follow-up (P < 0.05). Moreover, in the same group was present a statistically significant discs' shrinkage in the sixth month of follow-up (P < 0.05) as showed by IDVA. CONCLUSIONS: T2 shine-through effect in DWI is present before morphological disc reduction and moreover could be considered as a predictive sign of response to oxygen-ozone treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Ozônio / Quimiólise do Disco Intervertebral / Betametasona / Imagem de Difusão por Ressonância Magnética / Glucocorticoides / Disco Intervertebral / Deslocamento do Disco Intervertebral / Vértebras Lombares Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Radiol Med Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Itália País de publicação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Ozônio / Quimiólise do Disco Intervertebral / Betametasona / Imagem de Difusão por Ressonância Magnética / Glucocorticoides / Disco Intervertebral / Deslocamento do Disco Intervertebral / Vértebras Lombares Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Radiol Med Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Itália País de publicação: Itália