Your browser doesn't support javascript.
loading
Correlation and prognostic significance of MMP-2 and TFPI-2 differential expression in pancreatic carcinoma.
Zhai, Lu-Lu; Cai, Chong-Yang; Wu, Yang; Tang, Zhi-Gang.
Afiliação
  • Zhai LL; Department of General Surgery, Affiliated Provincial Hospital, Anhui Medical University Hefei 230001, Anhui Province, People's Republic of China ; Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery Hefei 230001, People's Republic of China.
  • Cai CY; Department of General Surgery, Affiliated Provincial Hospital, Anhui Medical University Hefei 230001, Anhui Province, People's Republic of China.
  • Wu Y; Department of General Surgery, Affiliated Provincial Hospital, Anhui Medical University Hefei 230001, Anhui Province, People's Republic of China.
  • Tang ZG; Department of General Surgery, Affiliated Provincial Hospital, Anhui Medical University Hefei 230001, Anhui Province, People's Republic of China ; Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery Hefei 230001, People's Republic of China.
Int J Clin Exp Pathol ; 8(1): 682-91, 2015.
Article em En | MEDLINE | ID: mdl-25755762
Aberrant expression of matrix metalloproteinase (MMP)-2 and tissue factor pathway inhibitor (TFPI)-2 not only correlate with tumorigenesis, but also with tumor invasion and metastasis. This study aims to investigate the correlation and prognostic significance of MMP-2 and TFPI-2 differential expression in pancreatic carcinoma. Immunohistochemistry was used to evaluate MMP-2 and TFPI-2 expression in tumor tissues and corresponding non-tumor tissues from 122 patients with pancreatic carcinoma. The results showed that the expression of MMP-2 was significantly (P < 0.05) higher in tumor tissues (78.7%) than in adjacent non-tumor tissues (27.9%), whereas the expression of TFPI-2 was significantly (P < 0.001) lower in tumor tissues (27.9%) than in adjacent non-tumor tissues (79.5%). Spearman's rank correlation test showed a negative correlation between MMP-2 and TFPI-2 expression (r = -0.346, P < 0.001). Kaplan-Meier survival analysis showed that high MMP-2 expression was significantly correlated with decreased disease-free survival (DFS) (P < 0.001) and overall survival (OS) (P < 0.001), while high TFPI-2 expression was significantly associated with increased DFS (P < 0.001) and OS (P < 0.001) of the patients. Multivariate analysis showed that high MMP-2 expression can act as an independent predictive factor for poor DFS (P = 0.01); and low TFPI-2 expression as an independent prognostic factor for poor DFS (P < 0.001) and OS (P < 0.001). In conclusion, our findings suggested that the differential expression of MMP-2 and TFPI-2 have a negative correlation in pancreatic carcinoma tissues; they may be considered as valuable biomarkers for prognosis of pancreatic carcinoma.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Glicoproteínas / Biomarcadores Tumorais / Metaloproteinase 2 da Matriz Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Clin Exp Pathol Assunto da revista: PATOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Glicoproteínas / Biomarcadores Tumorais / Metaloproteinase 2 da Matriz Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Clin Exp Pathol Assunto da revista: PATOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos