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An Update on Animal Models of Autoimmune Hepatitis: Are we There Yet?
Christen, Urs; Hintermann, Edith.
Afiliação
  • Hintermann E; Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Theodor-Stern Kai 7, 60590 Frankfurt am Main, Germany. christen@med.uni-frankfurt.de.
Curr Pharm Des ; 21(18): 2391-400, 2015.
Article em En | MEDLINE | ID: mdl-25777755
Autoimmune hepatitis is characterized by a progressive destruction of the liver parenchyma and a chronic fibrosis. Although the major targets of this autoimmune-mediated disease have been identified more than two decades ago, the current treatment of autoimmune hepatitis is still based on traditional therapies including a glucocorticoid treatment. One reason for this impasse is the limited availability of reliable animal models that reflect the clinical features of autoimmune hepatitis and allow for the identification of critical factors driving the autoimmune destruction and the evaluation of innovative therapies. However, the status of the liver as an immune privileged organ harbouring many immunosuppressing mechanisms hampers the development of such models. Here we will review the past and present attempts to develop a consistent animal model for autoimmune hepatitis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite Autoimune / Modelos Animais de Doenças Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Curr Pharm Des Assunto da revista: FARMACIA Ano de publicação: 2015 Tipo de documento: Article País de publicação: Emirados Árabes Unidos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite Autoimune / Modelos Animais de Doenças Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Curr Pharm Des Assunto da revista: FARMACIA Ano de publicação: 2015 Tipo de documento: Article País de publicação: Emirados Árabes Unidos