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Cytotoxic effects of solvent-extracted active components of Salvia miltiorrhiza Bunge on human cancer cell lines.
Sung, Bokyung; Chung, Hye Sun; Kim, Minjung; Kang, Yong Jung; Kim, Dong Hwan; Hwang, Seong Yeon; Kim, Min Jo; Kim, Cheol Min; Chung, Hae Young; Kim, Nam Deuk.
Afiliação
  • Sung B; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
  • Chung HS; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
  • Kim M; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
  • Kang YJ; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
  • Kim DH; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
  • Hwang SY; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
  • Kim MJ; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
  • Kim CM; Department of Biochemistry, School of Medicine, Pusan National University, Yangsan 626-770, Republic of Korea.
  • Chung HY; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
  • Kim ND; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
Exp Ther Med ; 9(4): 1421-1428, 2015 Apr.
Article em En | MEDLINE | ID: mdl-25780445
Herbal extracts and dietary supplements may be extracted from the medicinal plants used in traditional Chinese medicine, and are used increasingly commonly worldwide for their benefits to health and quality of life. Thus, ensuring that they are safe for human consumption is a critical issue for the preparation of plant extracts as dietary supplements. The present study investigated extracts of Salvia miltiorrhiza Bunge (S. miltiorrhiza), traditionally used in Asian countries to treat a variety of conditions, as a dietary supplement or as an ingredient in functional foods. Dried S. miltiorrhiza root was extracted with various solvents and under varying extraction conditions, and the effects of the extracts on the viability of five human cancer cell lines were compared. Extracts obtained using 100% ethanol and 100% acetone as solvents exhibited more potent effects compared with extracts obtained using 70 and 30% aqueous ethanol. Furthermore, the active components of S. miltiorrhiza ethanol extracts, known as tanshinones, were investigated. Dihydrotanshinone I was observed to exhibit a higher cytotoxic potential compared with the other tanshinones in the majority of the examined cell lines. Conversely, cryptotanshinone exhibited weak anti-cancer activity. In summary, the results of the present study suggest that the active components obtained from an ethanol extract of S. miltiorrhiza possess the potential to be used as ingredients in functional and health care foods that may be used to improve the effectiveness of chemotherapeutics in the prevention and/or treatment of cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Aspecto: Patient_preference Idioma: En Revista: Exp Ther Med Ano de publicação: 2015 Tipo de documento: Article País de publicação: Grécia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Aspecto: Patient_preference Idioma: En Revista: Exp Ther Med Ano de publicação: 2015 Tipo de documento: Article País de publicação: Grécia